“2 random pills” and shoebox pill. Take the shoebox pill, get a shoebox filled with the 2 random pills (since you got one they became “real”). Grab a big handful of pills and swallow.
Others (in case you don’t want to collapse civilization or piss gasoline):
Shoebox + any question = practically unlimited questions. Plus the first one should be something like “how can I achieve maximum happiness (in an easy way where current me would be comfortable with the results)?” and you can ask variations to get a clearer answer since you have practically unlimited ones. Only drawback is if “single-use” really means the duplicates don’t do anything.
Shoebox + groundhog day = probably get to live >10000 years (unless “single-use” prevents that)
Shoebox + pi money = practically unlimited money, no “single use” issue
Shoebox + kill one person = Death Note
Mario’s been watching too much Fox News, they should’ve never brought TVs and cable to Peach’s castle.
Look at all those gorgeous lines, truly the peak of UX engineering
I misread the last one as “Drugs as work, happy hours”.