I use a Kensington Expert Mouse for the last 10 years. It has 4 programmable buttons (plus 4 combos) a huge encoder wheel for scrolling and a large trackball in the center. I use it with my whole hand and the biggest advantage is that I just need to move my arm to the left (I use it with my left hand) to grab it. It is pretty fast to switch from the keyboard to the trackball and vice versa. I can even share my left hand palm rest with it. You can see some pictures here.
Welcome to this rabbit hole. I recommend the KeymapDB and the other references linked in my keymap repo.