So quick disclaimer, both my wife and I are on the Autism spectrum, we both figured this out far too late in our 20s and have been working to re-frame our mindsets about it to understand ourselves better.
Recently, she reached out to a Psychiatrist for adhd and PMDD symptoms and was immediately clocked as ASD and prescribed zoloft to help long term with PMDD syndromes.
The first night was absolute hell of mood swings and discomfort so I was looking more into SSRIs, previously all I knew is you cant just stop taking them and they make certain people’s dicks stop working.
Strolling into the zoloft subreddit is an absolutely crazy experience, half the posters are like “i’m going insane is this normal?” and they receive responses like “yeah just wait 12 weeks of these symptoms and maybe you’ll be cool”. The other half of the posts are people post 12 weeks being like “this shit cool”, but there’s a weird confirmation bias where the people who got off of it are not lurking in the zoloft subreddit. Every once and a while you’ll see someone necro-bump a year old post about someone giving it time and they’ll be like “oh yeah sorry for the late reply, the drug was incredibly bad for me and I had to get off of it”.
My wife was experiencing this out-of-character rage at certain things, but also felt a weird control over said rage and began looking into posts about that and apparently its common? Weird rage too, like being frustrated with fellow ASD people. I started connecting the dots and thinking about people in my life who were on these and holy shit, they’re absolute seething assholes to us, is this why? What is this drug???
And this doesn’t even touch getting off the drug, apparently the withdrawal is absolutely demonic for many many days. Then you have serotonin syndrome, the endless list of side effects that you have no idea if you’ll experience or not because doctors don’t give a shit and blood panels for drug reactions are too expensive to bother with.
All this stuff basically points to “neurodivergent people are being tortured with the promise of a semblance of normalcy in order to cope with our capitalist world, and all the “normalcy” is, is the ability to control your emotions externally despite them being wildly out of control internally”.
Rip me apart for this all you want but i’m leaning towards crank status being anti-anti-depressants. All this to say I’m prescribed stimulants and i’m grateful I can just take days off or just not take them when I’m happy to be my autistic-adhd self.(I know not all people can do this with ADHD, my heart goes out to them, but it’s more an issue with existing at baseline rather than going off wrecking havoc)
psyilocibin therapy needs to become more widespread because SSRIs are far more terrifying than seeing god and your subconscious.
I have ADHD myself and a sibling on the ASD spectrum, so likely on it a bit mysel, (by what my psychiatrist has told me). I wanted to briefly add my experience to what the wonderful commenter that you replied to.
First, there are some genetic medicine blood tests that can be helpful in predicting how one will react to psychoactive drugs. My wife had such screening after bad reactions to several medications. Basically, there are known variants of the genes involved in the structures of neurons and there is a large amount of data that has been correlated to these variants in patients and/or the mechanisms through which the medicines work. With this information, drug familes can be eliminated or recommended based upon likelihood of effectiveness or adverse reaction. Being neurochemistry, however, it’s still not exact and trying different medications may still be necassary.
Now, my personal experience. I started on an SNRI last year, after hitting what turned out to be weird hormonal issues that caused me to have periodic bouts of extreme anxiety. The one that I’ve used is closely related to the one mentioned by the previous commenter, desvenlafexine. It’s an active metabolite of venlafexine, meaning that it has a more rapid onset for effectiveness as the body doesn’t need to metabolize venlafexine into its active form. I found that improved my resilience significantly with hormone-driven issues (since mostly corrected) and with the overlap in activity with ADHD meds (stims act as dopamine and norepinepherine reuptake inhibitors) there seems to be improvement in those symptoms as well. Note however, that SNRIs can also modulate how stimulants work, even caffeine. So, it’s important to be careful with those - I’ve mostly stopped having morning coffee.