Years ago I tried modding Fallout New Vegas and I think 4 on Fedora ages (I was running Fedora 28 at the time) ago using Mod Organizer 2 and it wouldn’t work for reasons I didn’t understand, possibly file system related. I’m thinking of switching to Pop! OS full time but I’d still like to play either modded Skyrim or FO4 from time to time, preferably using MO2.
I seem to remember having to download the mods and put them in MO2 manually.