On my Mint installation, Firefox running causes my sound to crackle. If I try the same site (say, Odysee) in Midori or Chromium, everything is normal while Firefox isn’t running, but with Odysee playing, if I so much as open Firefox and let it sit on the landing page, my sound will begin to crackle until I decide to close it, at which time it quits in a few seconds. It also sounds like crap when I try to send Firefox to Odysee. It’s the same for if I send it to another site, like YouTube or Pandora, as well as finding videos on r/BreathOfTheWild via Reddit.
I acutally didn’t make any chanes to the system beyond just install the userspace apps I like, like Cura, Telegram, and the like, though I will look into Pipewire.