This is proving hard to visualize from just a picture but I think it’s the column with the most numbers. There isn’t enough room for the empty space between the bottom 1 and 3 to NOT be a block

So that makes the block in the 1 4 row the 4 and then you know the 1 goes in the first column.

I think. Double check before you commit lol

16th row, 4th column has to be filled or else there isn’t enough space for all the numbers above that. And that makes two adjacent filled, so you can finish the entire 16th row since it’s a 1 and a 4. That will probably get you enough help to fill in more

I’m no sudoku expert but I think at least (4,12) can be solved.